High-density lipoprotein (HDL) cholesterol is known as “good” cholesterol because it helps prevent arteries from becoming clogged. Higher LDL cholesterol levels mean higher risk. LDL cholesterol can build up on the inside of artery walls, contributing to artery blockages that can lead to heart attacks. Elevated lipoprotein (a), another type of fat (lipid) in your blood.Age older than 45 if you’re a man, or older than 55 if you’re a woman.

In addition, two or more of the following risk factors also might place you in the very high risk group:

Artery blockages in your arms or legs (peripheral artery disease).

Artery blockages in your neck (carotid artery disease).

You’re considered to be at a high risk of heart disease if you have or have had any of the following: There is no evidence that really low LDL cholesterol levels are harmful. In general, the lower your LDL cholesterol level is, the better. If you’re at very high risk of heart disease, you may need to aim for an LDL level below 70 mg/dL (1.8 mmol/L).

If you have other risk factors for heart disease, your target LDL may be below 100 mg/dL (2.6 mmol/L). Most people should aim for an LDL level below 130 mg/dL (3.4 mmol/L). Your target LDL number can vary, depending on your underlying risk of heart disease. Because LDL cholesterol is a major risk factor for heart disease, it’s the main focus of cholesterol-lowering treatment.

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